Abstract:Osteoblast is the key cell for bone formation and bone repair in vivo. Studies have found that a variety of natural products have certain regulatory effects on the differentiation of osteoblast, including natural products from plants, animals and microorganisms. Studies mostly focus on plant-derived natural products, including flavonoids, polysaccharides, alkaloids, saponins and some coumarins, lignans terpenoids and polyphenols, but there are few studies on the effect and mechanism of osteogenic differentiation by natural products from animals and microorganisms. Moreover, most of them focus on the regulatory effects of individual natural products. Therefore, in the future work, researchers can broaden the selection range of natural products and conduct a more comprehensive study of synergistic effects, providing a theoretical basis for natural products in the treatment of bone diseases.